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The metabolite ratios were generated from all unique combinations of the metabolites except 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), 4-ethylphenylsulfate (4-EPS) and dodecanedioic acid where 90% of the measurements were below the LLOQ

A second mechanism suggests that biased agonism, such as activity on the MC4R-G q pathway, may mitigate pressor effects while maintaining anorectic activity (66, 153)